一、課程基本資料 Course Information | ||||||||||||||||||||||||||||
科目名稱 Course Title: (中文)微生物遺傳學 (英文)MICROBIAL GENETICS |
開課學期 Semester:110學年度第1學期 開課班級 Class:微生四 |
|||||||||||||||||||||||||||
授課教師 Instructor:陳宜龍 CHEN, YI-LUNG | ||||||||||||||||||||||||||||
科目代碼 Course Code:BMB31801 | 單全學期 Semester/Year:單 | 分組組別 Section: | ||||||||||||||||||||||||||
人數限制 Class Size: | 必選修別 Required/Elective:必 | 學分數 Credit(s):3 | ||||||||||||||||||||||||||
星期節次 Day/Session: 一789 | 前次異動時間 Time Last Edited:110年09月27日12時54分 | |||||||||||||||||||||||||||
微生物學系基本能力指標 Basic Ability Index | ||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||
二、指定教科書及參考資料 Textbooks and Reference (請修課同學遵守智慧財產權,不得非法影印) |
||||||||||||||||||||||||||||
●指定教科書 Required Texts 無 ●參考書資料暨網路資源 Reference Books and Online Resources 1. Tina M. Henkin and Joseph E. Peters (2020). Molecular Genetics of Bacteria (5th ed.). New York: American Society for Microbiology Press. 以及先前的版本 2.Lori A.S. Snyder (2020). Bacterial Genetics and Genomics (1st ed.). New York: Garland Science. 3. 德利卡(2002)。DNA的14堂課。(周業仁譯)。臺北縣三重市:天下遠見。(原著出版年1997年)。 4. 分子生物學:輕輕鬆鬆學分生(朱雲瑋,蔡淳淳,曾慶宗,伍偉鴻譯)(2015)。新北市:藝軒。(原著出版年2010)。 5. 陳文盛(2019)。孟德爾之夢:基因的百年歷史(1版再修訂)。臺北市:遠流。 6.道納、史騰伯格(2018)。基因編輯大革命:CRISPR如何改寫基因密碼、掌控演化、影響生命的未來。(王惟芬譯)。臺北市:遠見天下文化。(原著出版年2017年)。 7. 賈德森(2009)。創世第八天:二十世紀分子生物學革命,首部曲DNA。(楊玉齡譯)。臺北市:遠流。(原著出版年1996)。 8. 賈德森(2009)。創世第八天:二十世紀分子生物學革命,二部曲RNA。(楊玉齡譯)。臺北市:遠流。(原著出版年1996)。 9. 賈德森(2009)。創世第八天:二十世紀分子生物學革命,三部曲蛋白質。(楊玉齡譯)。臺北市:遠流。(原著出版年1996)。 10. Bacterial Genetics and Genomics Blog: https://bacterialgeneticsbiology.science.blog | ||||||||||||||||||||||||||||
三、教學目標 Objectives | ||||||||||||||||||||||||||||
本課程著重於細菌分子遺傳學及細菌基因體學。 學生將學習DNA、RNA和蛋白質分子合成之間的關係,並透過遺傳變異與基因水平移轉了解微生物在環境中的演化。 細菌一直是人們對其遺傳學進行廣泛研究的對象,除了病源菌對人類健康的影響外,也是因為細菌生長快速、易於培養,易於操作,因此可以瞭解到大量的遺傳學原理。 隨著基因組學領域的發展,我們對細菌遺傳學的認識和研究細菌遺傳學的方法也發生了變化。基因組學比遺傳學的範圍更廣,它關注的是生物體內所有的DNA,而不是單個基因或一小部分。細菌遺傳學和細菌基因組學這兩個研究領域相互補充,相互影響。現在我們可以用測序方法將任何細菌的整個基因解開。遺傳學和基因組學再也無法分開。 |
||||||||||||||||||||||||||||
This course focuses on bacterial molecular genetics and bacterial genomics. Students will learn the relationship between DNA, RNA and protein synthesis, and understand genetic variations and horizontal gene transfer on the evolution of microorganisms. Bacteria have been the subject of extensive research into their genetics, both because of the roles for some of these in human disease and also because these organisms are easy to grow, easy to manipulate. Therefore a great deal can be learned about the principles of genetics. Our understanding of bacterial genetics and how we investigate bacterial genetics has changed as the genomics field has advanced. Genomics is wider in scope than genetics, being concerned with all of the DNA in an organism, rather than a single gene or small portion. These two research fields, bacterial genetics and bacterial genomics, complement each other and influence each other. Now we can lay bare the whole genome of any bacteria using sequencing methods. Genetics and genomes can no longer be separated. |
||||||||||||||||||||||||||||
四、課程內容 Course Description | ||||||||||||||||||||||||||||
●整體敘述 Overall Description 依照第一本參考書的架構 Introduction Chapter 1. The Bacterial Chromosome: DNA Structure,Replication, and Segregation Chapter 2. Bacterial Gene Expression: Transcription, Translation, Protein Folding, and Localization Chapter 3. Bacterial Genetic Analysis: Fundamentals and Current Approaches Chapter 4. Plasmids Chapter 5. Conjugation Chapter 6. Transformation Chapter 7. Bacteriophages and Transduction Chapter 8. Transposition, Site-Specific Recombination, and Families of Recombinases Chapter 9. Molecular Mechanisms of Homologous Recombination Chapter 10. DNA Repair and Mutagenesis Chapter 11. Regulation of Gene Expression: Genes and Operons Chapter 12. Global Regulation: Regulons a Chapter 13. Genomes and Genomic Analysis Part I. DNA, Genes and Genomes DNA Genes Genomes Part II. RNA, Transcriptional Regulation and Transcriptomes RNA Transcriptional regulation Transcriptomes Part III. Proteins, Structures, and Proteomes Proteins Protein Folding and Structure Multiprotein System and Proteomes Part IV. Genetics, Genomics and Bioinformatics Genetics Genomics Bioinformatics Part V. Bacterial Response Adaptation and Evolution Bacterial Response Bacterial Adaptation Bacterial Evolution Part VI. Gene Analysis, Genome Analysis, and Laboratory Techniques Gene Analysis Techniques Genome Analysis Techniques Laboratory Techniques Part VII. Applications of Bacterial Genetics and Genomics Biotechnology Infectious Disease Bacteriophages |
||||||||||||||||||||||||||||
●分週敘述 Weekly Schedule |
五、考評及成績核算方式 Grading | ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
六、授課教師課業輔導時間和聯絡方式 Office Hours And Contact Info | ||||||||||||||||||||||||||||
●課業輔導時間 Office Hour 星期一,15:10-17:00 |
||||||||||||||||||||||||||||
●聯絡方式 Contact Info
|
七、教學助理聯絡方式 TA’s Contact Info | |||||
| |||||
八、建議先修課程 Suggested Prerequisite Course | |||||
普通微生物學 生物化學 | |||||
九、課程其他要求 Other Requirements | |||||
十、學校教材上網及教師個人網址 University’s Web Portal And Teacher's Website | |||||
學校教材上網網址 University’s Teaching Material Portal: 東吳大學Moodle數位平台:http://isee.scu.edu.tw 東吳大學Tronclass行動數位平台:https://tronclass.scu.edu.tw |
|||||
教師個人網址 Teacher's Website: | |||||
其他 Others:TronClass課程邀請連結邀請 https://tronclass.scu.edu.tw/course/join/8HOYOSY9CAR | |||||
十一、計畫表公布後異動說明 Changes Made After Posting Syllabus | |||||